Topics discussed include the science behind why we age and interventions for slowing and even reversing aging. (00:00:00) Introduction (00:03:49) Thanking the Sponsors Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. Brilliant Brains is a deep, deep - no holds - dive into the minds of some of the most fascinating thinkers and wellness experts out there. (00:09:32 Biological Adversity & the Survival Circuit Welcome to the mind of David Sinclair, PhD , one of the world's leading scientific authorities on longevity, aging and how to slow its effects. (00:45:42) Hair Loss and Hair Graying They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Before we get to Brother Sadiki, Nuri Muhammad previews this weekend's Saviors Day event. Are you compulsively gambling, drinking, shopping, or even reading romance novels just to fall asleep? Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. #591 - Critical Drinker - Why Does Modern Cinema Suck So Much? (00:17:44) Three Longevity Pathways: mTOR, AMPK, and Sirtuins The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Cinema is no longer just about entertainment, it's now a platform for social and cultural ideologies to be pushed through. David clarified on the recent podcast with Rhonda Patrick that the NMN doesn't need to be taken with a fat source - he specifically mentions taking his NMN in capsules, downed with a glass of water in the morning. This article has some show notes and a commentary on David Sinclair's new podcast (and a link to the video).. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. * Levels - https://levels.link/sinclair kawasaki mule 610 alternator. * Levels - https://levels.link/sinclair Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. * Athletic Greens - https://athleticgreens.com/sinclair (00:13:56) Peptide Supplementation and Regenerative Signaling (00:32:35) Fatty Acids (00:35:48) Physical Activity The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. (00:39:14) Metformin Supplements and Highlight Points(00:09:54) Longevity Molecules Target the Survival Circuit(00:11:33) NAD Boosters(00:13:32) Nicotinamide Riboside(00:21:26) Nicotinamide Mononucleotide(00:29:22) NAD Intravenous Drips(00:32:45) Bioavailability of NAD Boosters(00:33:40) NAD and Cancer(00:35:33) Resveratrol(00:42:26) Red Wine and the French Paradox(0043:08) Fisetin and Quercetin(00:47:09) Rapamycin and Rapalogs(00:49:10) Spermidine(00:51:27) Metformin(01:00:27) Berberine(01:02:43) Dr. Sinclairs Protocol for Longevity Molecules(01:08:51) Wrap-up and Next Weeks Episode: Interventions on the Cutting Edge(01:09:52) Options for Subscription and SupportFor the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. (00:24:03) Vigorous Exercise, Hypoxia, the Electron Transport Chain Timestamps: Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. El experto en longevidad de Harvard Medical School, el profesor David Sinclair, nos desvela sus secretos para vivir ms y mejor. The Science of Keeping the Brain Healthy | Episode 7. (01:08:07) A Basic Protocol for Mimicking Adversity * Levels - https://levels.link/sinclair No credit card needed. (00:04:39) Thanking the Sponsors random podcast topics. We all encounter unresolved pain from our past, or what my guest today, , Dr David Ley is a clinical psychologist and a board member of the Sexual Health Alliance whose research focuses on issues related to sexuality, pornography and mental health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. . My goal in creating this podcast is to discuss the science behind why we age and to share the newest research on what we can do to slow, stop and even reverse aging. For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. Dr. Sinclair's paper, published last month in Cell. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. (00:28:15) Collagen, Keratin, and Skin Health Unveiling the stories behind the very special people who have devoted their life to people. If you're new to the show, please check out episode #195 for Marco's full backstory and episode #271, which features a panel discussion Marco and I conducted before a live audience at the Miami . (00:47:09) Rapamycin and Rapalogs Episode 5: Medical Interventions (TRT, HGH, Stem Cells, Peptides, etc.) Life lessons from the smartest people on the planet. NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4. (00:36:40) Using Personalized Data to Inform your Diet In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. 0:00 Intro 0:41 Story 2:34 Motivations 3:47 Building Doctify 8:25 Why do you have grit? (00:34:45) Autophagy and Retinoids (0:34:24) Genetics Influence How an Intervention Affects Aging massage west hollywood. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. Select a membership level. (00:49:47) Hyperbaric Oxygen Therapy * Levels - https://levels.link/sinclair Each episode offers tactical steps one can take to improve their wellbeing and achieve their goals from the world's top health experts in their field. Chris Twitter: https://twitter.com/RealCSharp Chris Instagram: https://www.instagram.com/christopher Liberation Times Twitter: https://twitter.com/LiberationTimes Liberation Times Website: https://www.liberationtimes.com/ SUPPORT DISCLOSURE TEAM !, Paul Sinclair is recognised within the field of unexplained phenomena for his honest no nonsense approach to the subject. Mission: extend lifespan. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks. Each week Ill be featuring inspirational stories and practical tips from some of my former guests. 89,911 views 1 year ago Welcome to Lifespan with Dr. David Sinclair. Lifespan book: https://amzn.to/3sUqurT (1:04:12) Obesity, Eating Habits, and Aging (00:28:19) Exercise Increases Glucose Sensitivity and Stimulates Blood Vessel Formation The investigation was filmed and released , I hit 700k Subscribers on YouTube!! (1:06:44) Preview for Ep. He is also the author of the best-selling book Lifespan: Why We Age & Why We Don't Have To, and is the host of the Lifespan Podcast. (01:07:04) Adversity Mimetics Produce Endorphins Join Dr. David Sinclair, Ph.D. in Lifespan, a popular health podcast that brings the cutting edge of aging and longevity science straight to you. We cover food, fasting and fitness. Restricting calories "works". Biotracking, Age Reversal & Other Advanced Health Technologies, Medical Interventions (TRT, HGH, Stem Cells, etc.) In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. royal military police ranks. For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. * Facebook The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Health has become overcomplicated. For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. (00:41:44) Botox, Skin Peels, and Microneedling (00:25:05) Exosome Therapy Dr. David Sinclair Social: In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. Before Dr. Fox, Griot Professor James Small will discus, Learning to harness the power of your breath can be life changing. Sign up free. This podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. Previous research on aging and DNA mutations. In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for med Sunday morning sermons from Clemson Presbyterian Church. The Human Upgrade with Dave Aspreyformerly Bulletproof Radio. Matthew LaPlante's Social: 0:00. Don't snack. As always there's some great questions in here about whether Ray Dalio is coming on the podcast, how to overcome negative self talk and whether I'll be doing a , Have you ever had a moment or experience, maybe even an entire season of life that was so hard, so filled with struggle and, maybe even, grief, loss and uncertainty, that the very idea of feeling or accessing any kind of big or meaningful or sustained happiness or joy just completely left you? January 12, 2022. In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. This podcast can also be found on YouTube: https://www.youtube.com/davidsinclairpodcast (0:40:00) Things to Avoid: Excess Sugar and Protein They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. (00:37:59) Stem Cell Aging and Cord Blood Banking (00:11:33) NAD Boosters Thank you to our sponsors: (00:50:33) Increasing Blood Flor Review our. Given the rise of dating apps, the sexual revolution and hormonal birth control, how is this happening? * Levels - https://levels.link/sinclair What does it mean to live a good life? To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. * Facebook (0:08:04) Caloric Restriction is an Evolutionarily Conserved Anti-Aging Strategy Over the last 589 episodes, 1000+ hours and nearly 2000 days of working away on this project I've learned a lot, and today I'm going through some of the most important lessons and, What if you were, unknowingly being controlled by unresolved pain from your past, even minor, or momentary experiences, ones that took root and, from that moment on, without you having any idea, limited everything from your relationships to your health, work, wealth, and life? The health entrepreneurship podcast focusing on big picture stuff. His podcast contains 9 episodes with the latest episode updated on February 23, 2022. Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3. Humans have the capacity for incredible benevolence and kindness, but also are able to be execute other members of our species with a , Futuristic Researcher Sadiki Bakari takes over our classroom to update us on the latest A. I Artificial Intelligence developments. For Longevity, NMN, NR, Resveratrol, Metformin & Other Molecules for Longevity. A range of supplements. The 54-year-old Fremont, California native, who covers music, celebrities, and pop culture on Wild 94.9 as well as his podcast shows, was last seen at his home in San Francisco at 10pm Thursday,. In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. Please subscribe, share with friends, leave a comment or review, and most of all, thank you for coming with us on this journey into the mechanisms of aging and exploration of the tools for living longer, healthier lives! 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